There currently is one option to travel by night bus from Prague (Czech Republic) to Rome (Italy), taking approximately 20 hours: Namely the BUS Praha - Řím operated by Regiojet.

Next offers

Regiojet operates both night trains and night buses across Europe, providing various travel options. Regiojet night trains offer a range of cabin options, from standard reclining seats in open compartments to private couchette cabins designed for one to four travelers, complete with bedding and duvets for a restful journey. Wifi is available and breakfast and coffee are served for free. Regiojet night buses feature ergonomic seating that can recline for comfort, with generous legroom and amenities such as USB charging ports, free WiFi, personal entertainment screens, and complimentary refreshments available during the journey. There is also a toilet on the bus.

For the next 7 dates with connections, the cheapest offer starts at 57 EUR. Check our connection pages below for all availabilities!

Next available offers

Mon, 09.06.2025

from 65 EUR

Fri, 13.06.2025

from 93 EUR

Mon, 16.06.2025

from 73 EUR

Fri, 20.06.2025

from 73 EUR

Mon, 23.06.2025

from 57 EUR

Fri, 27.06.2025

from 65 EUR

Mon, 30.06.2025

from 57 EUR